Pressing Ctrl+Shift+R for Hard Refresh (instead of Ctrl+R for Normal Refresh) may not always invalidate cache of the page that you are currently viewing.
If you want to truly reload page from server (bypassing local copy stored in cache) then you must:
- Press Ctrl+Shift+I to open Dev Tools for a moment
- Right-click Refresh button in the toolbar
- Click Empty cache and hard refresh option in context menu
Since Edge is based on Chromium, the very same trick will work in Chrome as well.
Source: Super User.